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KMID : 0383820060610060591
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Tuberculosis and Respiratory Diseases
2006 Volume.61 No. 6 p.591 ~ p.594
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Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Adjuvant Chemotherapy with Cisplatin plus Paclitaxel in Non-Small Cell Lung Cancer Patient
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Baek Yong-Soo
Ryu Jeong-Seon
Hong Seong-Bin
Yoo Sung-Soo
Yu Hyung-Kwon
Son Dong-Wook
Kim Lucia
Kang Hye-Sun
Kim Beom-Joon
Lee Kyung-Hee
Cho Jae-Hwa
Yoon Young-Han
Kwak Seung-Min
Lee Hong-Lyeol
Kim Kwang-Ho
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Abstract
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We report a case of pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following adjuvant chemotherapy. A 51-year-old woman with stage IIIA adenocarcinoma received left lower lobe lobectomy in July, 2006. And then combination chemotherapy with paclitaxel and cisplatin was given to the patient. In five days after completion of second cycle of the chemotherapy, she visited emergency room because of general weakness and seizure. Her brain MRI was shown to be no evidence of brain metastasis. Serum sodium, urine and plasma osmolarities were 117mEq/L, 589 and 244mOsm/kg, respectively. She was improved with fluid restriction. Although occurrence of SIADH following chemotherapy is rare, physician should give an attention the potential for development of SIADH in the course of chemotherapyin non-small cell lung cancer patient.
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KEYWORD
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Syndrome of inappropriate secretion of antidiuretic hormone, Chemotherapy, Non-small cell lung cancer, Seizure
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